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Cough Suppressant Now a Proven Cancer Remedy

By Lee Euler / October 24, 2012

Could it be possible that a heavy-hitting cancer cure is right under our noses — available over the counter?

So it would seem.

It’s called noscapine. No matter how you look at it, this naturally-occurring compound that comes from poppy flowers appears to be a winner. It’s backed by solid science and has virtually no side effects. A researcher who participated in one of the studies said noscapine could be the most effective tumor-suppressant ever. Keep reading for more about this overlooked wonder.

Continued below. . .

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Noscapine has been used for years in over-the-counter cough medicines. But taken in high doses, it becomes a near-perfect cancer treatment — operating almost like chemotherapy, but without all the consequences.

The long road to “getting discovered” as a cancer treatment

    The best source of noscapine is opium-producing poppy plants, but it can also be found in tomatoes and cabbage leaves. First discovered back in 1817, it’s a compound with a colorful history. Originally (in the late 1800s) noscapine was used to treat malaria — though it wasn’t very effective. Then in the 1930s, researchers realized noscapine had anti-cough properties. By 1958, it was used worldwide as a cough suppressant.

About that time, the National Cancer Institute ran some cell culture studies and realized noscapine had cancer-killing properties. But the substance was already patented as a cough suppressant, so further studies on anti-cancer benefits were dropped. Sponsoring drug companies didn’t want to bother since they had no way to make a profit. The patent would run out before they could satisfy the FDA that noscapine is an effective cancer medicine.

This is hard to believe, but it’s true. If you wonder why the health care system is so dysfunctional, look no further.

Fast-forward to 1997, when a grad student at Emory University School of Medicine in Atlanta, Georgia — Keqiang Ye — rediscovered that noscapine kills cancer.

Emory scientists jumped on it and studied the effect of noscapine on human breast cancer tumors transplanted into animals. Results showed 80-percent tumor reduction in as little as three weeks, and with no obvious toxicity to vital organs. Immune systems in the animals also stayed functional, in direct contrast to the immune-suppressing effects of chemotherapy.

More studies followed, including one where noscapine was proven effective against malignant melanomas and certain kinds of brain cancer.

It was also confirmed that high, daily doses of noscapine were not only non-toxic, but that side-effects in humans were rare. One patient out of five would experience only mild side effects, like nausea and stomachache. I should add that noscapine users occasionally abuse the product, because a high dose is intoxicating. After all, it’s an opium derivative.

Following the slew of promising studies, Emory scientists worked with scientists from the University of Delhi, in India, to chemically modify noscapine so they could get it patented and on the market as a cancer treatment.

By 2004, they had a new agent (but with the same anti-cancer properties). It was patented, and from there Emory gave Cougar Biotechnology of California the go-ahead to make a commercial version. In July 2009, Cougar Biotechnology was acquired by Johnson & Johnson as a wholly-owned subsidiary, but still manages preclinical trials of noscapine.

In other words, it’s not FDA-approved yet as a cancer remedy, but many cancer patients are taking advantage of it anyway, since it’s available over the counter.

I don’t personally know any patients who have tried it nor do I know what’s considered a therapeutic dose. Because it’s an opium product and may have the potential to be addictive, I can’t recommend noscapine for unsupervised home use until I have more information. It’s an exciting development, but still new and experimental.

In May we sent members of our “platinum club,” the Alternative Cancer Research Institute, the first breaking news we had about noscapine. ACRI is dedicated to gathering every single alternative cancer remedy on earth into one place. We have more than 350 so far.

In spite of that enormous number of treatments, we keep coming across new ones, or important new information about treatments we already list. So twice a month ACRI members receive breaking news about a new cancer treatment.

PLUS when you join we send you a free 460-page soft cover book with all the treatments. The book is called the Complete Guide to Alternative Cancer Treatments. And it has a better claim to that boastful title than any other book on earth. We’ve shown it to research scientists who were in awe when they saw all the cancer treatments we’ve been able to gather.

If you’d like to learn more about ACRI, just click here.

Meanwhile, getting back to noscapine. . .

Three-fold anti-cancer properties

    The anti-cancer potential of noscapine is impressive. For starters, it has powerful cell-killing abilities, meaning it can stop cell division. As a result, cancer cells can’t replicate and spread.

Noscapine also stops angiogenesis — the formation of new tumor vessels that feed tumors. Inhibiting angiogenesis is a major goal of any cancer treatment. Noscapine can do this thanks to its ability to inhibit HIF-1 alpha. For science buffs, HIF-1 alpha is a transcription factor that supports VEGF, or vascular endothelial growth factor, which stimulates the growth of new blood vessels.

A third major benefit to this natural compound is that it inhibits bradykinin, which is a powerful cancer growth factor. Some studies show that agents with the ability to inhibit bradykinin are more effective than chemotherapy drugs at halting cancer cell growth.

As a result of these anti-cancer abilities, some doctors already use noscapine to treat the following cancers: breast, prostate, lung, ovarian, brain, and lymphomas.

Beyond that, the research continues to impress. In 2010, Current Drug Targets published a study that showed noscapine not only inhibited the growth and spread of leukemia cells, but also made them more vulnerable to chemotherapeutic agents.

Then last February, Medical Research published the results of a study that proved noscapine significantly induced apoptosis, or natural cell death, of Mg-63 tumor cells (found in osteosarcoma, a common type of bone tumor). It was one of the researchers involved in this study who said noscapine could be the most effective tumor-suppressant ever discovered.

There’s even a doctor in San Diego — Dr. Israel Barken — known to treat his prostate cancer patients with noscapine. Dr. Barken posted study results on his website that showed noscapine curbed prostate cancer tumor volume in mice by significant amounts.

But here’s what we’re waiting on…

    Now that the healing properties of noscapine are more well-known, cancer patients are using it to treat themselves. You can get it over the counter in most countries, and that includes the U.S. and Canada. In addition, we’re seeing more and more reports of noscapine working where chemotherapy or conventional drugs fail.

Development is something of an issue, since producing noscapine can be labor-intensive (it requires the cutting open of individual poppy seed capsules). But a new study published online in Science last May shows promise for synthesizing noscapine to make production faster and easier.

So the future looks bright for this treatment. It’s widely available, relatively cheap, has a good safety record, works synergistically with other drugs, and has low toxicity. Plus, more and more studies are confirming the pros of this promising natural substance.

Where we go next depends largely on the results of future studies and whether the medical community will embrace it as a standard cancer treatment.

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Kindest regards,

Lee Euler, Publisher


References:“A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine.” Winzer et al. Science, Published Online 31 May 2012.
https://www.sciencemag.org/content/336/6089/1704.abstractChang, Raymond, MD, FCAP. (2009, May 11). Noscapine near perfect? Off-Label Cancer Treatments. Retrieved on March 12, 2012 from:
http://cancerx.wordpress.com/2009/05/11/is-noscapine-near-perfect/Landen, J., Hau, V., Wang, M., Davis, T., Ciliax, B., Wainer, B., Van Meir, E., Glass, J., Hoshi, H., Archer, D. Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth. Clinical Cancer Research. 2004, Aug. 1; Vol. 10: 5187. Retrieved March 12, 2012 from:
http://clincancerres.aacrjournals.org/content/10/15/5187.fullLucas, D., Still, P., Bueno Pérez, L., Grever, M., and Kinghorn, A. Potential of plant-derived natural products in the treatment of leukemia and lymphoma. Current Drug Targets. 2010, July; 11(7): 812-822. Retrieved March 12, 2012 from:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892601/“Noscapine.” http://en.wikipedia.org/wiki/NoscapineNoscapine: A Safe Cough Suppressant With Newly Discovered Effects in Treating Cancer and Stroke. (2007, Feb.) MedInsight Research Institute in Collaboration with Prostate Cancer“Noscapine near perfect?” By Dr. Raymond Chang, Off-Label Cancer Treatments.
http://cancerx.wordpress.com/2009/05/11/is-noscapine-near-perfect/Noscapine Project. Prostate Cancer Research and Education Foundation.
http://www.noscapine.org/

Product Pipeline. Cougar Biotechnology, Research and Development.
http://www.cougarbiotechnology.com/pipeline.html

“Prophylactic noscapine therapy inhibits human prostate cancer progression and metastasis in a mouse model.” Barken I, Geller J, Rogosnitzky M. Anticancer Res. 2010 Feb;30(2):399-401.
http://www.ncbi.nlm.nih.gov/pubmed/20332445

Research and Educational Foundation St. Dover, DE. Retrieved on March 11, 2012, from:
http://www.pcref.org/MedInsight%20-%20PCREF%20Noscapine%20Review.pdf

Rosenberg, Mark MD. (2009, May 16). Noscapine and Cancer.
http://noscapine.com/cancer.html

“Scientists Identify Opium Poppy Genes that Make Promising Cancer Drug.” By Maia Szalavitz, TIME Magazine, Healthland. 6 June 2012.
http://healthland.time.com/2012/06/01/scientists-identify-opium-poppy-genes-that-make-promising-cancer-drug/

The Effect of Noscapine Combination of Cisplatin on Inhibition Proliferation and Apoptosis of Human Osteosarcoma Cell Line MG-63. (2012, Feb. 22) Medical Research. Retrieved on March 11, 2012 from:
http://www.res-medical.com/oncology/62207

About the author

Lee Euler

Hi I'm Lee Euler, I’ve spent over a decade investigating every possible way a person can beat cancer. In fact, our commitment to defeating cancer has made us the world’s #1 publisher of information about Alternative Cancer Treatments -- with over 20 books and 700 newsletters on the subject. If you haven't heard about all your cancer options, or if you want to make sure you don’t miss even one answer to this terrible disease, then join our newsletter. When you do, I'll keep you informed each week about the hundreds of alternative cancer treatments that people are using to cure cancer all over the world.

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