Saffron has been revered for its medicinal properties for 3,500 years. This highly prized spice appears in the works of Hippocrates, Galen and other famous clinicians of ancient times.
It’s so expensive that fake or adulterated saffron is a common problem today – and likewise centuries ago, when sellers of fraudulent products were burned in the market place or buried alive.
As long as you make sure you’re buying the real deal, the health benefits are many, including fighting cancer AND Alzheimer’s disease. . .
It’s a remarkable spice. . .
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A treasured sign of spring
might help save your life
Saffron is harvested from the dried, delicate, dark red or yellow stigmas of the crocus flower, Crocus sativus. These pollen-catching tendrils are best known as a coloring and flavoring ingredient.
Up north, crocus flowers are just about the earliest sign of spring – which is always welcome after you’ve slogged through winter. For this reason, crocuses are a special delight, and it’s nice to think they also yield a delicious food – and a powerful medicine to boot.
Many cultures around the globe use saffron in their food, although 90% of the world’s commercial production comes from just one country, Iran.
One gram of saffron (1/28th of an ounce) costs around $10 to $20. Its high price reflects the fact that it’s still cultivated and harvested by hand. It takes more than 50,000 crocus flowers — enough to spread across an entire football field — to produce a single pound of the spice.
But on the other hand, most dishes require just a tiny amount.
Saffron has many uses in traditional medical systems. These include coughs and colds, stomach problems, flatulence, uterine bleeding, insomnia, heart disease and cancer.
Studies today demonstrate that saffron’s many bioactive components help to counteract risk factors for heart disease, diabetes and stroke. It has potential as a neuroprotective and eye support agent, and may even have a role in weight loss.
Other studies have shown improved oxygenation in lung and brain tissues and protective effects in the bladder and liver against chemically induced damage.
In our brain health division, we recently learned a top expert, a Columbia professor, uses it extensively to treat people with dementia. He’s seen even advanced Alzheimer’s patients respond to medicinal saffron.
Taken as a supplement, it’s most commonly used to alleviate depression. But its greatest potential may lie in the prevention and treatment of cancer.
Contains potent plant pigments and oils
Over 150 different components have been identified in saffron stigmas. The most powerful of these are crocin, picrocrocin, crocetin and safranal.
Crocin and crocetin are plant pigments (carotenoids) that give saffron its deep color. Picrocrocin and safranal are oils. The first gives saffron its bitter taste and the second provides the aroma.
In laboratory studies, these compounds have demonstrated favorable effects in cancer. They can slow down and even reverse tumor growth, prevent DNA modifications that induce mutations, and help reduce the damage caused by chemotherapy drugs.
Saffron protects against most if not all factors that help cause cancer, whether these are viruses, free radicals, inflammation, radiation or toxins.
- The spice inhibited tumor markers on the surface of cells infected with viruses.
- Tumor formation was prevented in hamsters given strong carcinogenic chemicals.
- A topical application of saffron extract impeded cancer from developing in mice that were exposed to a carcinogen used to induce skin cancer.
- Saffron also obstructed damage to DNA caused by inflammation, free radicals and radiation.
Inhibits growth of multiple tumors
Once the cancer process begins, it reproduces or proliferates. Normal control mechanisms fail to limit its growth. In lab cell cultures, saffron suppressed proliferation and, in some human cells, even reversed it.
For instance, when saffron extract and crocin were tested on three different types of human colorectal cancer cells, proliferation was reduced down to 52%, 16.8% and 2.8% compared to untreated cells.
Significant inhibition of growth was also observed in non-small cell lung and breast cancer cells. It had no effect on, and didn’t damage, normal cells.
In culture, crocetin inhibited proliferation of highly aggressive pancreas cancer cells. In mice injected with such cells, then given crocetin by mouth after the tumor had grown, there was “significant regression in tumor growth with inhibition of proliferation.”
In another experiment, different strengths of saffron extract were injected into rats with stomach cancer. Those treated with higher doses were “completely normal” at the end of the experiment, and no rats in any of the saffron treated groups had tumors.
Beneficial effects have also been found in liver, prostate, skin and blood cancers.
Triggers apoptosis: One important method of stopping cancer growth is by inducing apoptosis or programmed cell death. Cancer cells are normally able to evade self-destruction, but powerful apoptosis properties have been demonstrated in crocin, crocetin and safranal in different cancer cell lines including stomach, lung, cervix and liver.
Impedes angiogenesis: Cancer cells are able to grow by forming new blood vessels, a process called angiogenesis. A great deal of scientific research has been dedicated to creating drugs that can block this action and thereby starve tumors from the oxygen and nutrients they need to sustain growth.
Vascular endothelial growth factor (VEGF) helps new cancer-supporting blood vessels to grow. Saffron extract and crocetin have both been shown to reduce levels of VEGF.
Curbs metastasis: The ability of cancer to spread to different areas of the body is what makes it so deadly. Few people actually die of cancer confined to its original site. Cancer cells are able to metastasize by dissolving collagen and connective tissues that surround them, using enzymes called matrix metalloproteinases. These are raised above normal parameters in active cancer.
Crocetin was shown to down-regulate these enzymes in breast cancer cells.
Exciting findings from Dr. Amin’s lab
Scientists from United Arab Emirates University have published thirteen studies on saffron. One of these was on colorectal cancer in 2012, and another, published in 2016, was on liver cancer. Lead researcher Dr Amr Amin commented:
“Animals administered with crocin before getting [colorectal] cancer showed almost no sign of the disease compared with untreated animals. In those protected animals, tumor cells divided less, died more and were associated with less inflammation. All that was very encouraging.
“We then looked at the effect of crocin on human liver cancer cells and found very much the same results – cells stop dividing, tend to die more and to have much less inflammation in the presence of crocin.”
Dr. Nagi B. Kumar, professor of oncologic sciences at the University of South Florida, commenting on the most recent study, said the UAR team’s work “clearly demonstrates crocin’s anti-inflammatory, pro-apoptotic and anti-proliferative effects against liver cancer. The results of this study are encouraging and offer great promise to the field of cancer chemo-prevention.”
Protects against chemotherapy toxicity
Chemotherapy is known to be so harmful to healthy cells that it can provoke DNA damage and induce the very thing it is designed to destroy.
In three separate studies by the same research group, mice were treated with one of three or four different chemotherapy drugs. Before they did so, the researchers gave saffron extract to the mice. This significantly reduced cellular DNA damage.
In a separate experiment to see its effect on antioxidant systems, pre-treatment with saffron extract reduced the damage caused by free radicals and increased several antioxidant and detoxification systems.
Other studies show that saffron can also enhance the effectiveness of some chemotherapy drugs and protein-based vaccines which treat certain types of tumors.
Best ways to buy and use saffron
Although research into saffron’s anti-cancer properties has been ongoing since 1990, there are no human studies, but the evidence for its protective properties is strong, in my opinion.
For cancer prevention, regular intake in supplement form is the best option. Just be aware that the amount required is not known, and long term safety issues have not been fully addressed.
Even so, toxicology studies (studies to determine if a substance is damaging) suggest it is safe to use at the recommended dose of 30 mg per day.
In cooking, while saffron is expensive, little is needed to flavor and color dishes. It’s popular in rice and seafood meals and can be added to soups, sauces and stews.
But do make sure you buy saffron from a reliable source.
Since we no long burn sellers of fake saffron, or bury them alive, you need to be on the lookout to make sure of obtaining the genuine article. The Columbia Professor I mentioned earlier recommends Optimized Saffron from the Life Extension supplement brand.
Our last issue also had good news – there may finally be more accurate tests for prostate cancer, to take the place of the PSA test. If you missed the news (including how to keep from undergoing needless surgery and biopsies), scroll down and read it now.
Finally, New Prostate Cancer Tests
That are Better Than PSA
Prostate cancer is the second most common cancer among men in the US. Of the 30 million men who will be screened this year, an estimated 180,000 will be diagnosed.
It’s also the second most common form of cancer death for men, with more than 26,000 fatalities per year. This is sad, because all prostate cancers are considered 100% curable if they’re caught early enough.
Unfortunately, there’s a lack of accurate, dependable screening tests to help us find this disease early. Even though doctors themselves have largely lost faith in the PSA test, it’s still pretty much the only game in town.
But, at long last, some better tests are on the horizon. . .
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A quick look at the PSA blood test
In 1994, the FDA approved a blood test to screen for Prostate-Specific Antigen (PSA). PSA is a protein made by the prostate in response to disease or inflammation. Elevated levels of PSA in the bloodstream are an assumed indicator of prostate cancer, or prostatitis, or infection. . .or something.
Before the PSA test was implemented, about 70,000 men a year were diagnosed with prostate cancer.
By the early 2000s, that number had risen to over 200,000. You might think this is a good thing – doctors were finding cancers that previously went undetected, so those men could get treatment and lives could be saved.
Well, that’s not how it worked out. Most prostate cancers are relatively harmless. An estimated nine out ten grow very slowly, and a man can live a very long time without knowing he has a tumor – or caring.
The saying used to be, “Most men die with prostate cancer, not of it.” They went to their graves never knowing they had a “problem.”
Now, with the coming of the PSA test, vast numbers of slow-growing cancers are discovered and removed surgically or treated with radiation. The common side effects of the treatments – impotence, incontinence, a general loss of vitality – last a lifetime. Another risk is infections resulting from surgery or a hospital stay.
Is the tumor aggressive?
At the same time, I want to be clear that one prostate tumor out of ten IS aggressive. That’s frightening if you’re told you have a high PSA score or if a biopsy finds cancer cells. And if you have a high PSA score, you can be sure your doctor will start pushing a biopsy at you.
A biopsy involves punching into the prostate with a needle, in a number of places, to take samples of tissue. The samples are analyzed for the presence of cancer cells.
Men are afraid they’ll draw the wrong number in the lottery and be the one guy out of ten who has aggressive prostate cancer. When a patient has heard the C-word, most of the time he’s demanding surgery before the doctor even has a chance to suggest it. So a high PSA scores leads to biopsies leads to surgery, even with a nine-in-ten chance that the surgery could have been avoided or put off for years.
Just to be safe, about 60,000 men will undergo surgery and radiation therapy for low-risk cancer.
The statistics show that all this “precautionary” treatment has not saved lives.
You don’t have to take my word for it: In 2013, the American Urological Association came to the conclusion that our current tests lead to needless biopsies, which lead to risky surgeries to remove non-life-threatening prostate cancers.
Perhaps this is the most important fact: The number of prostate cancer deaths remained about the same, around 30,000, before and after the frantic increase in prostate cancer surgery and other treatments.
The basic problem is to distinguish aggressive from slow-growing prostate tumors.
In aggressive cases, surgery and radiation therapy are a necessity. These conventional solutions are usually effective provided the cancer is confined to the prostate. (Less damaging alternative treatments are available, and you can check them out in my Special Report, Don’t Touch My Prosate!)
But in low-risk, slow-growth cases, annual monitoring is all that’s required to keep an eye on the disease’s progression.
3 new tests that may help narrow it down
Doctors are looking at a new regimen of screening tests that can be done to better determine if a prostate tumor is aggressive.
The first is a simple urine test:
Exosome Diagnostics, a company out of Cambridge, Massachusetts, has developed a method of studying exosomes in urine samples.
Exosomes are messengers between cells that allow cancer to spread. The RNA inside these exosomes can yield clues as to whether prostate cancer is present and whether it’s aggressive or low-risk.
From the patient’s perspective, few things could be easier than a urine test, and it could stop a lot of worry before it occurs.
A top executive at Exosome Diagnostics has expressed concern that urologists will resist the new test, because they can make a lot more money doing a biopsy. Let’s hope urologists take a more constructive attitude.
I would ask my doctor to look into this test before subjecting myself to a biopsy. Here’s their website: http://www.exosomedx.com/
The second test is called the 4K score:
This is a variation on the PSA blood test mentioned above. This version more accurately determines the aggressiveness of the disease and scores that on a scale.
The score is used to decide whether a biopsy is necessary, which can save time and money on the patient’s behalf. Prostate biopsies — I’m told by people who know — are extremely painful. They should be a last resort.
These first two tests will hopefully cut back on the number of needless biopsies done per year. But in cases where a biopsy turns out to be necessary, new testing is required to find out whether further treatment will be needed.
Please know this: While a biopsy can confirm whether cancer is present, it still doesn’t tell us whether it’s aggressive or not. But there’s a new hope. . .
How to get more information out of a biopsy
The third test is called the Prolaris, a genetic analysis performed on biopsied tissue. A company called Myriad Genetics of Irvine, California is carrying out these tests.
They determine the risk that a patient will die from the disease within the next ten years. With this information, a patient and his doctor are in a better position to decide on next steps.
Other genetic tests are being developed for use when a biopsy results in a negative, to ensure that the cancer wasn’t missed previously or that it hasn’t spread elsewhere.
A more informed choice
This combination of tests is awaiting approval from the FDA. The first of the three may be available already – I was unable to get a definitive answer on this.
But experts are already pointing toward these new tests as a safer, fairer and more honest method of evaluating your choices and putting together a treatment plan.
This article is about detection, not treatment, but I do want to say that if you have an early-stage prostate tumor – especially one that doesn’t seem to be aggressive – it’s definitely worth trying alternatives.
With rare exceptions, you have plenty of time to try healthy food, exercise, and anticancer supplements, as well as infrared sauna and other detoxification methods. And I can tell you from personal experience (it worked for me) that this approach can eliminate prostate tumors without invasive treatments.
References Article #1: