Are you a fan of hot spicy food that makes your mouth feel like it’s on fire?
Personally, I love hot foods – and for once, something I like is good for me!
Scientists are finding that hot spices are especially suited to fight cancer. Capsaicin — the natural compound in those foods that burns your tongue — also turns the heat up on cancer cells and helps keep them from spreading.
It’s a natural wonder, and here’s how it works. . .
Capsaicin is the ingredient that makes hot chili peppers hot, and at the same time it offers a dream list of exactly the things you would look for if you were searching for a natural substance that can cut off cancer at the knees1…
- Blocks genes that help cancer survive.
- Arrests the growth of tumors.
- Stops the extra blood supply that cancer latches onto for nutrients.
- Stymies the metastatic spread of cancer throughout the body.
Persuading cancer to kill itself
Capsaicin often induces cancer cells to commit self-induced suicide, a process called apoptosis that I’ve often discussed in these pages.
The interesting part of capsaicin’s role in this process is that it can attack cancer cells in several different ways. Each one of them has the same cancer-destroying result.
For instance, it can go after cancer cells’ mitochondria, the little organelles that supply the cells with the energy to survive. According to researchers at the University of Maryland, because mitochondria are so central to cancer cell survival – a cell without mitochondria would be like an automobile without an engine – the mitochondria are the “gatekeepers” of the apoptosis process.
So when capsaicin throws a monkey wrench into mitochondrial function, cancer cells conk out like cars ready for the junk heap.2
Added to that, capsaicin can also activate a gene in cancer cells called p53 – a “tumor suppressor.” This gene is involved in the formation of proteins that also lead to apoptosis in cancer cells.3
Keep cancer from traveling
Another important trait of capsaicin is its ability to keep cancer from traveling around the body and invading other organs. Most people who die of cancer do so because of this process – called metastasis. It’s not the cancer in the original site that kills them.
When cancer metastasizes, it becomes more resistant to treatment. That’s a big reason metastatic cancer accounts for about four out of five cancer deaths.4
“Lung cancer and other cancers commonly metastasize to secondary locations like the brain, liver or bone, making them difficult to treat,” says researcher Jamie Friedman. “Our study suggests that the natural compound capsaicin from chili peppers could represent a novel therapy to combat metastasis in lung cancer patients.”
A rare remedy for pancreatic cancer
Capsaicin’s ability to disable and kill pancreatic cancer cells has also drawn a great deal of attention from researchers. Pancreatic cancer is among the top five cancer killers. The survival rate after five years for this type of cancer is less than ten percent.6
So any answer to pancreatic cancer is rare and precious. Capsaicin appears to be one. It’s been shown to induce apoptosis.
Researchers at the University of Pittsburgh School of Medicine say the spice helps direct oxidative damage to mitochondria in cancer cells that makes them self-destruct.
Plus, other researchers are demonstrating that when capsaicin is combined with other “bioactive food components,” the therapeutic effect on cancers is upped considerably.
For example a study at the University of Bordeaux in France shows that a combination of capsaicin and resveratrol – an antioxidant found in wine, peanuts, grapes and blueberries – can keep cancer cells from being able to repair damage to their DNA.
When this repair mechanism bogs down, cancer cells are less likely to reproduce and they become more vulnerable to the damage that takes place during radiation therapy – the professional word for this is “radiosensitized.”7 Likewise, they also become easier to kill with chemotherapy.8
In today’s society, given our huge appetite for processed food and our national problem with carrying too much weight around our middles, we’re experiencing an epidemic of impaired liver function, and the fat tissue that accumulates in this hard-working organ has become a health danger.
Here too, capsaicin may help. When liver issues give way to liver cancer, research in Asia shows that capsaicin can step in and cause liver cancer cells to self-destruct because of oxidative stress.9
In addition, a lab study at the University of Wyoming School of Pharmacy demonstrates that a drug based on capsaicin can, before cancer develops, potentially make “improvements in blood sugar and cholesterol levels, insulin response, and symptoms of fatty liver disease,” according to researcher Baskaran Thyagarajan. In this drug, capsaicin is basically modified to improve absorption by the body.
The tests indicate that this version of capsaicin stimulates receptors in fat cells to burn off energy instead of stashing an ever-increasing supply within their cell membranes. And that can lead to weight loss and shrinkage of the liver’s fat cells.10
Other benefits of capsaicin include:
- Fights against triple-negative breast cancer: This aggressive malignancy is highly resistant to the most common chemo drugs. According to research in Germany, capsaicin can latch on to the receptors in these types of tumors and possibly lead to “significant inhibition of cancer cell growth and induced apoptosis.”11
- Protects against heart disease and improves life expectancy: Tests at the University of Vermont found that eating hot peppers lowered the risk of dying by 13 percent during the 19-year study.12 The improved longevity was mainly due to a decrease in the risk of heart attack or stroke. The researchers believe that chili peppers and capsaicin alter the probiotic bacteria in the digestive tract in ways that promote better cardiovascular health.
Now, anyone who has ever tasted a fiery entree spiced with hot chili peppers can testify that they contain something “unique” – and not everyone likes it. But capsaicin is not popular with cancer cells, either. I hope to see further research into how it can be used to keep cancer under control.
And meanwhile I think I’ll have a jalapeno-stuffed olive and make a reservation at an Indian restaurant.