This issue I’m pleased to announce an exciting development. It emerged very recently from medical research in New York, but it’s already available at certain alternative cancer clinics we recommend.
It works for many types of cancer, and you can get it now from at least one doctor I know and highly respect.
This therapy targets cancer cells while leaving normal cells untouched. It has only minor side effects and – unlike many cancer therapies -- does not result in making cancer stronger in the long run by failing to kill cancer stem cells. With most treatments, cancer stem cells survive and morph into new cancer strains that are immune to the treatment.
Not with this one.
From what we’ve been able to learn here at Cancer Defeated, this would be among the top therapies I would consider if I had cancer...
Continued below…
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Designed by supercomputer
Back in 2000, Dr. Matthew Pincus and colleagues designed synthetic proteins called PNC. Members of the Pincus team were affiliated with New York Harbor Veterans Administration Medical Center and the State University of New York Downstate Medical Center.
Their tool was a powerful supercomputer that could perform molecular modeling and three-dimensional simulations of proteins and nucleic acids.
The strategy was to create molecules that could block a protein called MDM-2 to prevent it from inhibiting the p53 gene, famously called the tumor suppressor gene.
The scientists in this study tested a version of their synthetic PNC protein on ten different types of human tumors in a culture dish. In each case all the cells were killed. Some lines of breast cancer were killed in as little as 30 minutes. Other cell lines, such as pancreatic and non-small cell lung cancer, took 72 hours. They called this version of the protein PNC-27.
The next test was to see what effect it had on healthy pancreatic and lung cells. In each case these cells were not affected by PNC-27. They remained alive, their shape and structure untouched.
The researchers then added a dye to a human pancreatic cancer cell to stain a part of it. Just one minute after adding PNC-27 the cell could be seen to shrink, roll up, lift and die.
Cancer cells die in an unexpected way
Taking the same cell and looking at it under a scanning electron microscope where the surface of the cell could be observed, the scientists were astonished by what they saw. When PNC-27 was added, the cancer cell did not die by apoptosis. It died by necrosis.
Pores were formed throughout the cell membrane allowing fluids to enter. This disrupted the osmotic balance and the integrity of the cell, causing it to die. This happened so quickly the cancer cell had no time to repair or survive.
This process activated no biochemical pathways. It is a purely mechanical action. Holes are literally burrowed into the walls of the cancer cell membrane.
Exactly the same process was demonstrated in twelve other tumor cell lines, but there was no destructive pore formation when PNC-27 was added to healthy cells.
In the journal Cancer Therapy in 2007 the scientists wrote, "Surprisingly, we have found that these peptides induce 100 percent tumor cell necrosis, not apoptosis, in 13 different human cancer cell lines, but have no effect on normal pancreatic cancer cells, breast epithelial cells, and human stem cells."
A study published in 2014 tested PNC-27 against human leukemia cell lines called K562. The scientists wrote that "PNC-27 is selectively cytotoxic to K562 cells inducing nearly 100% cell killing."
The most recent study, published in November 2015, concluded that PNC-27 has potential "as an efficient alternative treatment of previously untreated ovarian cancer as well as for ovarian cancers that have become resistant to present chemotherapies."
Here’s how PNC works...
So what is it that’s causing cancer cells to roll over and die while healthy cells continue on their way? The explanation is somewhat complicated, but we have many doctors and scientists among our readers who will want to know. (If you don’t, just skip to the next section.)
As I mentioned earlier, the synthetic protein PNC is designed to block a protein called MDM-2 to prevent its binding to p53.
The p53 gene is known as the guardian of the human genome because of its importance as a tumor suppression protein. It ensures proper DNA replication and hinders cancer cell production.
If a fault is discovered in the cell, this gene is activated to repair it. If the repair fails, P53 can signal the cell to commit suicide (apoptosis).
p53 is controlled by MDM-2 through a feedback mechanism. When the cell is under no stress, p53 is inactive, but when it comes under stress, MDM-2 becomes under-expressed, allowing p53 activity to increase and carry out repairs.
However, in up to 60% of cancers MDM-2 (called HDM-2 in humans) is over-expressed, and this prevents p53 from carrying out its functions.
The theory is that blocking HDM-2 should boost p53 activity and induce the cancer cell to die by apoptosis (assuming p53 is still functional. In most cancers it becomes mutated and is no longer active).
As you've already seen, all the evidence confirms that the theory is not only right – it’s right in spades.
Kills cancer in a number of ways
It seems that cancers that are advanced or aggressive express a high amount of HDM-2 not only in the nucleus and mitochondria of the cell but also in the membrane. This does not happen in normal cells where HDM-2 activity in the membrane is extremely low.
This appears to be independent of p53 since the synthetic PNC protein killed cancer cells even where p53 was not functional. The basis of this pore formation remains unclear, but it’s known that HDM-2 promotes cancer growth other ways besides inhibiting the p53 anticancer gene.
One of these is by hindering another protein called E-cadherin -- a tumor-suppression protein within cell membranes. Blocking HDM-2 would increase E-cadherin’s activity.
Whatever the explanation for the effect, it’s an important discovery. The New York team was clearly on to something. Their next step was to test PNC on rodents. Dr. Pincus explains the results...
"We have further tested our peptides against the highly malignant, metastatic TUC-3 pancreatic cancer cell line in nude mice and find that they eradicate the tumor within two weeks of drug delivery."
Dr. Ehsan Sarafraz-Yazdi, one of the New York team, describes the drug as being "like a magic bullet." He says PNC-27 is better than chemotherapy because:
- It has its own built in delivery mechanism, being able to accumulate at the tumor site.
- It is targeted. Once it gets to the tumor site it acts on cancer cells, not normal cells.
- It uses pore-formation -- a novel way to kill cancer cells.
Treatment available in Mexico
PNC-27 is now available for cancer patients. It can be used in the form of suppositories or as a nebulizer as well as intravenously.
But if you know anything about the cancer industry, you won’t be surprised to learn it’s not available in the United States.
According to a website devoted to information about it, "major pharmaceutical companies have chosen not to engage in the support of these products. Since PNC is not available for medical use in the United States, many patients travel to Mexico or European countries to receive treatment."
There are only two facilities in Mexico where PNC-27 is available. These are The Northern Baja Healing Center led by Patrick Vickers and The Hope4Cancer Institute whose medical director is Antonio Jimenez, M.D.
Dr. Vickers' treatment protocol focuses on the Gerson method, but he also incorporates a number of other therapeutic options. He’s enthusiastic about PNC. "So far the results are incredibly promising. We’ve heard some really fantastic stories already coming out of our clinic where people with lung mets [i.e. metastases] or even brain mets have been nebulizing it and their metastasis had been resolved."
One example he relates is that of George, a young 'terminal' stage 4 colon cancer patient with metastasis to the lungs. Although progressing on the Gerson therapy, he was still in pain and had difficulty breathing, so he was put on PNC-27 by nebulizer where it travels directly to the lungs.
According to Dr. Vickers, "Literally within 3-4 weeks the scans showed negative. Symptoms were gone." Six months later he was cancer free.
Anytime a late-stage cancer patient becomes cancer free, it’s news.
Dr. Jimenez is also very enthusiastic. He writes in September 2015, "For more than a decade, there have been many promising studies on PNC-27 and cancer cells in rats, mice, and primates, plus extensive human studies conducted outside the United States. All point in the direction of PNC-27 being a true game changer in oncology."
Here at Cancer Defeated we’re old friends of Dr. Jimenez. His clinic is among those we highly recommend in our guide to Mexican alternative cancer clinics, The Amish Cancer Secret.
Dr. Jimenez cites the following...
Remarkable advantages of PNC-27
- highly selective to rapidly dividing tumors
- non-toxic
- doesn't affect other body systems
- no serious side effects
- does not stimulate cancer stem cells
- tumors cannot develop resistance to it
- can penetrate bone tissue to attack cancer cells located there.
- improves the quality of patients' lives.
Based on a limited number of cases so far, Dr. Jimenez says a patient can expect the following: In the first 30 days tumor activity decreases, less acid is formed, pain is reduced and mental clarity is enhanced, but fatigue increases and blood results go haywire because of the rapid tumor die-off. The blood picture will not improve for at least 12 weeks.
Dr. Jimenez’s in-clinic patients typically receive PNC-27 intravenously for 20 days and then take it by nebulizer and/or suppository, depending on the tumor sites, when they return home. Length of the therapy will vary but will be not less than three months.
He describes it as "a powerful and effective treatment" but emphasizes, as does Dr Vickers, that the therapy must be part of a comprehensive holistic health program.
Sometimes medical science produces a wonderful breakthrough like this one, but sometimes it produces an incredible blooper. Our last issue described one of the worst. If you missed it, you can read it just below...
Best regards,
Lee Euler,
Publisher
